Sensibilidad a la insulina está correlacionada con baja adiposidad y ejercicio físico. Según un estudio de cohortes sobre una población de mediana edad realizado en Tasmania (Australia) y publicado recientemente en el portal BMJ, la sensibilidad a la insulina aumenta al aumentar el número de pasos
diarios particularmente por una menor
adiposidad. A continuación el abtract y desarrollo del estudio (en inglés)
El estudio
recibió apoyo económico del Commonwealth Department of Health and Aged
Care, Abbott Australasia, Alphapharm, Aventis Pharmaceutical,
AstraZeneca, Bristol-Myers Squibb Pharmaceuticals, Eli Lilly,
GlaxoSmithKline, Janssen-Cilag, Merck Lipha, Merck Sharp & Dohme,
Novartis Pharmaceutical, Novo Nordisk Pharmaceutical, Pharmacia and
Upjohn, Pfizer, Roche Diagnostics, Sanofi Synthelabo, Servier
Laboratories, BioRad Laboratories, HITECH Pathology, la Australian
Kidney Foundation, Diabetes Australia, Diabetes Australia (Northern
Territory), Queensland Health, el South Australian Department of Human
Services, el Tasmanian Department of Health and Human Services,
Territory Health Services, Victorian Department of Human Services, y el
Health Department of Western Australia.
Un
autor del estudio fue apoyado económicamente por una beca para
Investigación en Salud Pública de la Victorian Health Promotion
Foundation, otro por una donación para mejorar la capacidad de salud de
la población de NHMRC y otro por una beca de investigación de NHMR.
Los demás autores del estudio han declarado no tener ningún conflicto de
interés económico pertinente.
Abstract
Objectives To investigate the association between change in daily step count and both adiposity and insulin sensitivity and the extent to which the association between change in daily step count and insulin sensitivity may be mediated by adiposity.
Design Population based cohort study.
Setting Tasmania, Australia.
Participants 592 adults (men (n=267), mean age 51.4 (SD 12.2) years; women (n=325), mean age 50.3 (12.3) years) who participated in the
Tasmanian component of the national AusDiab Study in 2000 and 2005.
Main outcome measures Body mass index, waist to hip ratio, and HOMA insulin sensitivity at follow-up in 2005.
Results Over
the five year period, the daily step count decreased for 65% (n=382) of
participants. Having a higher daily step count
in 2005 than in 2000 was independently
associated with lower body mass index (0.08 (95% confidence interval
0.04 to 0.12)
lower per 1000 steps), lower waist to
hip ratio (0.15 (0.07 to 0.23) lower), and greater insulin
sensitivity (1.38 (0.14 to 2.63) HOMA units higher) in 2005. The mean
increase in HOMA units fell to 0.34 (−0.79 to 1.47) after adjustment for
body mass index in 2005.
Conclusions Among community dwelling, middle aged adults, a higher daily step count at five year follow-up than at baseline was associated
with better insulin sensitivity. This effect seems to be largely mediated through lower adiposity.
Para acceder al estudio completo en su versión en inglés haga click aquí
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